منابع مشابه
Orexins: neuropeptides for all seasons and functions.
THE NEUROPEPTIDES OREXIN (ORX) A and B were first identified by a screen for novel hypothalamic homeostatic regulatory peptides (15). Because of the substantial homology in amino acid sequences with secretin, they were named hypocretins by one group (9). Because they stimulated food intake, they were called ORXs by another (42). While the relatively small number of ORX-expressing neurons are lo...
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The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known famil...
متن کاملSchistosome I/Lamides--a new family of bioactive helminth neuropeptides.
Here we report the identification of a new family of helminth neuropeptides with members in both nematodes and flatworms, and include preliminary cell biological and functional characterisation of one of the peptides from the trematode parasite of humans, Schistosoma mansoni. Bioinformatics and Rapid Amplification of cDNA Ends (RACE)-PCR were used to identify the complete S. mansoni neuropeptid...
متن کاملA new face of orexins action - neuroprotection
MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...
متن کاملA new family of (A, N)-implications: Construction and properties
This paper deals with a new family of (A, N)-implications that derived from fuzzy negation and continuous monotone function, and some properties, like the left neutrally, the exchange principle, the ordering property and the laws of contraposition, of the proposed family of (A, N)-implications are studied. Moreover, the T-conditionality and the Modus tollens for the new family of (A, N)-i...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1999
ISSN: 0007-0912
DOI: 10.1093/bja/83.5.695